Since switching to Ubuntu 12.04 I've moved to using Cinnamon as my DE. I did give Unity a serious go for a couple of weeks, but after one evening trying to use it to support a software release - switching between 3 browser windows and 2 SSH sessions, it became obvious it wasn't suitable. For many reasons, documented all over the web.
So I installed Cinnamon and despite a few teething problems (I think mainly caused by my nVidia card) it works beautifully. Nice weather, battery, and monitor applets; a simple, clean look, and easily configurable. As nice as Gnome used to be.
One issue I had recently though is that Wine applications place their menu items within the 'Other' area of the Menu (see this post), and when attempting to tidy this up, Cinnamon locked up and refused to restart. Even re-booting didn't solve the problem. I was kind of stuck as I couldn't see where the configuration was, or how it had failed. A remove/purge and re-install didn't fix anything (as configuration is held at user-level this is 'safe' to do. In that, you don't lose any settings/applets).
Incidentally, following this stack-exchange entry I found that deleting entries from ~/.local/share/applications/wine/Programs and again in the ~/.config/menus/applications-merged area achieved much the same thing as editing the menu in the DE, with less chance of issues(!)